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It is primarily transmitted to humans and animals through insect vectors, known as triatomine bugs or "kissing bugs", which are found mainly in the Americas. The disease affects millions of people in Central and South America, particularly in rural areas with poor housing conditions and limited access to healthcare. It can also be transmitted through blood transfusions, organ transplantation, or from mother to child during pregnancy. The symptoms of Chagas disease vary depending on the stage of infection. In the acute phase, patients may experience fever, fatigue, body aches, and swelling at the site of insect bite. However, many infected individuals remain asymptomatic or have mild symptoms that go unnoticed. If left untreated, Chagas disease progresses to the chronic stage, which may cause severe complications. These can include heart disease, digestive disorders, and damage to other organs, such as the liver and spleen. Diagnosis of Chagas disease can be challenging, as symptoms are often non-specific and may be mistaken for other diseases. Laboratory tests, including blood tests and serological assays, are used to confirm the infection. Currently, treatment options for Chagas disease are limited. Antiparasitic medications, such as benznidazole and nifurtimox, are the primary treatments available, but they are most effective during the early stages of infection. Managing the complications and symptoms of the disease is also an essential part of patient care. Prevention plays a crucial role in controlling Chagas disease. Measures like improving housing conditions, implementing vector control programs, and screening blood and organ donations have been effective in reducing transmission rates. Research for new treatments and development of a vaccine against the disease is an ongoing endeavor. Chagas disease remains an important public health issue in the Americas, with the potential for global spread due to globalization and climate change. International efforts are needed to raise awareness, improve surveillance, and ensure access to timely diagnosis and treatment for affected individuals.